4-(2,4,6-Trimethylbenzyl)-1,3-thiazol-2-amine
نویسندگان
چکیده
منابع مشابه
Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amines were potent cytotoxic agents against cancer cell lines, suppressed mitotic histone H3 phosphorylation, and caused aberrant mitotic phenotypes. It was subsequently established that these compounds were in fact potent inhibitors of aurora A and B kina...
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Supporting Figure 1. Kinase inhibitory activity of compound 18 . S2 Supporting Figure 2. Activity of compound 18 in tumor models S3 Synthesis and Characterization of Compounds 7h, 11–17, and 19–24 S4 Biopharmaceutical Profiling S7 Rat Pharmacokinetics S7 Cell Viability Assay S7 Murine P388/D1 Leukemia Model S7 NCI-H460 Xenograft S7 X-Ray Crystallography S8 Molecular Modeling S8 Supplementary Re...
متن کامل4-Ethoxypyridin-2-amine
The title compound, C(7)H(10)N(2)O, crystallizes with two independent mol-ecules in the asymmetric unit. The bond lengths and angles in the mol-ecules are within normal ranges. The crystal structure is stabilized by inter-molecular N-H⋯N hydrogen bonds, linking the two independent mol-ecules into hydrogen-bonded dimers.
متن کامل2-Chloropyrimidin-4-amine
In the title pyrimidine derivative, C(4)H(4)ClN(3), the 2-chloro and 4-amino substituents almost lie in the mean plane of the pyrimidine ring, with deviations of 0.003 (1) Å for the Cl atom, and 0.020 (1) Å for the N atom. In the crystal, molecules are linked via pairs of N-H⋯N hydrogen bonds, forming inversion dimers. These dimers are further linked via N-H⋯N hydrogen bonds, forming an undulat...
متن کاملN-(4-Chlorophenyl)-4-methylpyridin-2-amine
In the title compound, C(12)H(11)ClN(2), the dihedral angle between the benzene and pyridyl rings is 48.03 (8)°. Twists are also evident in the mol-ecule, in particular about the N(a)-C(b) (a = amine and b = benzene) bond [C-N-C-C = -144.79 (18)°]. In the crystal, inversion dimers linked by pairs of N-H⋯N hydrogen bonds result in the formation of eight-membered {⋯NCNH}(2) synthons [or R(2) (2)(...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2011
ISSN: 1600-5368
DOI: 10.1107/s1600536811006386